Home Health CDC Panel: No COVID-19 Vaccine Security Surprises

CDC Panel: No COVID-19 Vaccine Security Surprises


Jan. 27, 2021 — The U.S. is almost 6 weeks into its historic marketing campaign to vaccinate People in opposition to the virus that causes COVID-19, and to date, the 2 vaccines in use look remarkably low-risk, in response to new information introduced as we speak at a gathering of vaccine consultants that advise the CDC.

With 23.5 million doses of the Pfizer and Moderna vaccines now given, there have been only a few critical negative effects. As well as, deaths reported after individuals received the vaccine don’t appear to be associated to it.

The commonest signs reported after vaccination had been ache the place individuals received the shot, fatigue, headache, and muscle soreness. These had been extra frequent after the second dose. As well as, about 1 in 4 individuals reported fever and chills after the second shot.

“On the entire, I believed it was very reassuring,” mentioned William Schaffner, MD, an infectious illness knowledgeable with Vanderbilt College College of Medication in Nashville who listened to the displays.

The CDC is amassing security data by way of a number of channels. These embody a brand new smartphone-based app referred to as V-Safe, which collects each day data from individuals who’ve been vaccinated; the federal Vaccine Opposed Occasion Reporting System, or VAERS, which accepts studies from anybody; and the Vaccine Safety Datalink, which is a collaboration between the CDC and 9 main hospital methods. There’s additionally CISA, the Scientific Immunization Security Evaluation Undertaking, a collaboration between the CDC and vaccine security consultants.

After surveying these methods, consultants heading the protection committee for the CDC’s Advisory Committee on Immunization Practices say there have been few critical negative effects reported.

Very not often, extreme allergic reactions — referred to as anaphylaxis — have occurred after vaccination. There have been 50 of those instances reported after the Pfizer vaccine and 21 instances reported after the Moderna vaccine so far. Practically all of them — 94% of the anaphylaxis instances after Pfizer vaccines and 100% of these after Moderna’s vaccine — have been in ladies, although it’s not clear why.

That interprets to a fee of about 5 instances of anaphylaxis for each million doses of the Pfizer vaccine and about three for each million doses of the Moderna vaccine. Most of those happen inside quarter-hour after getting a vaccine dose, with one reported so long as 20 hours after the shot.

The CDC suspects these could also be associated to an ingredient referred to as polyethylene glycol, or PEG. PEG is part of the particles that slip the vaccines’ mRNA into cells with directions to make the spike protein of the virus. Cells then categorical these spikes on their surfaces so the immune system can be taught to acknowledge them and make defenses in opposition to them. PEG is a standard ingredient in lots of medication and infrequently triggers anaphylaxis.